Identification of drug-specific public TCR driving severe cutaneous adverse reactions
نویسندگان
چکیده
منابع مشابه
Severe Cutaneous Adverse Reactions
Severe cutaneous adverse reactions (SCARs) are generally induced by drugs and encompass the conditions of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), drug induced eosinophilia and systemic syndrome (DRESS) also known as drug induced hypersensitivity syndrome (DIHS), and acute generalized exanthematous pustulosis (AGEP). These conditions, although rare, cause significant...
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Background: Severe Adverse Cutaneous Reactions to Drugs (SACRDs) are skin eruptions due to drugs, which can cause morbidity and morbidity in patients. Objectives: The aim of this study was to determine the offending drug/agents and clinical phenotypes of SACRDs leading to admissions to the hospital. Materials & Methods: We conducted a retrospective cross-sectional study during one year (March...
متن کاملAdverse cutaneous drug reactions
| August 2014 | 798 Finally, the authors detected a higher prevalence of more serious and life-threatening types of ACDR like Stevens Johnson and toxic epidermal necrolysis in their study. This finding is so important and may be due to the difference in type and potency of metabolic pathways in Iranian patients due to their ethnic groups, or it may be due to not including the above mentioned ri...
متن کاملImmunohistopathological Findings of Severe Cutaneous Adverse Drug Reactions
Diagnosis of severe cutaneous adverse drug reactions should involve immunohistopathological examination, which gives insight into the pathomechanisms of these disorders. The characteristic histological findings of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) provide conclusive evidence demonstrating that SJS/TEN can be distinguished from EM. Est...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2019
ISSN: 2041-1723
DOI: 10.1038/s41467-019-11396-2